Yes, I agree with you. Those horses who have high sensitivity to insects of any kind must have a lowered immunity at least to that particular irritant, and an immune booster, especially all natural, makes a lot of sense. I always avoid internal meds unless I really know they are necessary and there are no better options. I think, too, that as horses age, just like us, they tend to have less ability to fight off things that would not have bothered them when they were younger. I have a 22 yr old gelding who is super sensitive to all sorts of meds, vaccinations, etc. It is really challenging to know what to do with him sometimes. Luckily, insects don't bother him as long as he has his fly mask and a good spray. He has terrible reactions to vaccinations, and went into bad colics that last 2 times we tried it. I have avoided them, with my vet's blessing but soon will have to think about trying at least some again. So far his titers have been very good but it's been nearly 2 years now. Glad your mare is so much better. It is so awful to know they are are in discomfort when you are trying to help, and the things are not working!